InhaltsangabePreface INTERACTIONS OF ALPHA-SYNUCLEIN WITH LIPIDS AND ARTIFICIAL MEMBRANES MONITORED BY ESIPT PROBES Introduction to Parkinson's Disease and Alpha-Synuclein Structural Biology of Alpha-Synuclein Methods for Studying AS-Lipid Interactions ASLipid Interactions Interactions of Monomeric AS with Artificial Membranes Monitored with ESIPT Probes Aggregation of AS and the Effects of Fatty Acids Monitored with ESIPT Probes Concluding Remarks STRUCTURAL AND FUNCTIONAL INSIGHTS INTO ALPHA-SYNUCLEIN-LIPID INTERACTIONS Introduction Interation of Alpha-Synuclein with Model Membrane Systems Biological Significance SURFACTANTS AND ALCOHOLS AS INDUCERS OF PROTEIN AMYLOID: AGGREGATION CHAPERONES OR MEMBRANE SIMULATORS? Introduction Aggregation in the Presence of Surfactants Palimspsets of Future Functions: Cytotoxic Protein-Lipid Complexes Aggregation in Fluorinated Organic Solvents From Mimetics to the Real Thing: Aggregation on Lipids Summary INTERACTION OF hlAPP AND ITS PRECURSORS WITH MODEL AND BIOLOGICAL MEMBRANES Introduction Results Conclusions AMYLOID POLYMORPHISMS: STRUCTURAL BASIS AND SIGNIFICANCE IN BIOLOGY AND MOLECULAR MEDICINE Introduction Only Generic Data Are Currently Available on the Structural Features of Amyloid Oligomers The Plasma Membrane Can Be a Primary Site of Amyloid Oligomer Generation and Interactions Oligomer/Fibril Polymorphism Can Underlie Amyloid Cytotoxicity Amyloid Oligomers Grown Under Different Conditions Can Display Variable Cytotoxicity by Interacting in Different Ways with the Cell Membranes Conclusions INTRACELLULAR AMYLOID BETA: A MODIFICATION TO THE AMYLOID HYPOTHESIS IN ALZHEIMER'S DISEASE Introduction Evidence for the Presence of Intracellular Amyloid Sources of Intracellular Amyloid Relationship Between Intracellular and Extracellular Amyloid Prevention of Intracellular Amyloid Toxicity Concluding Remarks Disclosure Statement LIPID RAFTS PLAY A CRUCIAL ROLE IN PROTEIN INTERACTIONS AND INTRACELLULAR SIGNALING INVOLVED IN NEURONAL PRESERVATION AGINST ALZHEIMER'S DISEASE Lipid Rafts: Keys to Signaling Platforms in Neurons Estrogen Receptors Are Part of Signaling Platforms in Neuronal Rafts Role of Lipid Raft ERAlpha-VDAC Interactions in Neuronal Preservation Against ABeta Toxicity Disruption of ERAlpha-VDAC Complex in AD Brains Future Studies ALZHEIMER'S DISEASE AS A MEMBRANE-ASSOCIATED ENZYMOPATHY OF BETA-AMYLOID PRECURSOR PROTEIN (APP) SECRETASES Introduction Intramembrane-Cleaving Enzyme of Type I Membrane Proteins Alcadein Processing by Gamma-Secretase in Alzheimer's Disease IMPAIRED REGULATION OF GLUTAMATE RECEPTOR CHANNELS AND SIGNALING MOLECULES BY BETA-AMYLOID IN ALZHEIMER'S DISEASE Introduction AMPARMediated Synaptic Transmission and Ionic Current are Impaired by ABeta CaMKII is Causally Involved in ABeta Impairment of AMPAR Trafficking and Function PIP2 Regulation of NMDAR Currents is Lost by ABeta The Effect of AChE Inhibitor on NMDAR Response is Impaired in APP Transgenic Mice ABeta Impairs PKC-Dependent Signaling and Functions Conclusion MEMBRANE CHANGES IN BSE AND SCRAPIE Prion Diseases The Cellular Prion Protein (Prpc) and Conversion to Disease-Associated Prion Protein (PrPd) PrPd Accumulation in the Central Nervous System and Lymphatic Tissues Aberrant Endocytosis and Trafficking of PrPd in Neurons and Tingible Body Macrophages Abnormal Maturation Cycle and Immune Complex Trapping of Follicular Dendritic Cells in Lymphoid Germinal Centers Molecular Changes of Plasma Membranes Associated with PrPd Accumulation Transfer of PrPd Between Cells Extracellular Amyloid Form of PrPd StrainDirected Effects of Prion Infection Conclusion and Perspectives Summary INTERACTION OF ALZHEIMER AMYLOID PEPTIDE WITH CELL SURFACES AND ARTIFICIAL MEMBRANES Introduction Comparison of the Neurotoxicity of Oligomeric and Fibrillar Alzheimer Amyloid Peptides ABeta Oligomerization at the Cell Surface Catalysis of ABeta Oligomerization b

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Currently at the department of Chemistry at Ben Gurion University, Israel, Raz Jelinek obtained his BSc in chemistry from the Hebrew University of Jerusalem, Israel, and his PhD from the University of California, Berkeley. He was a Cancer Research Institute post-doctoral fellow at the University of Pennsylvania and a Visiting Professor at the Department of Chemical and Biomolecular Engineering at Johns Hopkins University. Professor Jelinek has over 90 scientific publications and 10 patents to his name, and has received several scientific awards, including the Roger-Siegel-Brown Award of the Israeli Academy of Science and the Ruth L. Kirschstein National Research Service Award of the National Institutes of Health, USA.

Interactions of Alpha-Synuclein with Lipids and Artificial Membranes Monitored by ESPIT Probes Structural and Functional Insights Into Alpha-Synuclein Lipid Interactions Surfactants and Alcohols as Inducers of Protein Amyloid: Aggregation Chaperones or Membrane Simulators? Interaction of hIAPP and its Precursors with Model and Biological Membranes Amyloid Polymorphisms: Structural Basis and Significance in Biology and Molecular Medicine Intracellular Amyloid Beta: A Modification to Amyloid Hypothesis in Alzheimer''s Disease Lipid Rafts Play a Crucial Role in Protein Interactions and Intracellular Signaling Involved in Neuronal Preservation Against Alzheimer''s Disease Alzheimer''s Disease as Membrane-Associated Enzymopathies of APP Secretases Impaired Regulation of Glutamate Receptor Channels and Signaling Molecules by Beta-Amyloid in Alzheimer''s Disease Membrane Changes in BSE and Scapie Interaction of Alzheimer Amyloid Peptide with Cell Surfaces and Artificial Membranes Experimental Approach and Technical Challenges for Studying Amyloid-Membrane Interactions