InhaltsangabePart I. Introduction Immunostimulatory DNA: An Overview Eyal Raz Historical Perspectives Saburo Yamamoto, Toshiko Yamamoto, and Tohru Tokunaga Part II. Receptors and Signaling Signal Transduction Pathways Activated by CpG-DNA Hans Häcker A Novel TollLike Receptor that Recognizes Bacterial DNA Hiroaki Hemmi and Shizuo Akira Activation of Innate Immunity by Microbial Nucleic Acids WenMing Chu, Xing Gong, and Tony Yoon Phosphorothioate Backbone Modification Changes the Pattern of Responses to CpG Katryn J. Stacey, David P. Sester, Shalin Naik, Tara L. Roberts, Matthew J. Sweet, and David A. Hume Part III. Cell Activation Activation of NK Cell by Immunostimulatory Oligo-DNA in Mouse and Human Saburo Yamamoto, Toshiko Yamamoto, Tetsuro Kataoka, Sumiko Iho, and Tohru Tokunaga Regulation of Antigen Presenting Cell Function by CpG-DNA David Askew, Rose S. Chu, and Clifford V. Harding Activation of B Cells by CpG Motifs in Bacterial DNA, Ae-Kyung Yi and Arthur M. Krieg IFNDependent Pathways for Stimulation of Memory CD8+ Cells Jonathan Sprent Cross Priming of CD8+ T Cells by Immunostimulatory Sequence DNA Hearn Jay Cho, Sandip Datta, and Eyal Raz Part IV. Vaccination Strategies The Th1 Adjuvant Effect of Immunostimulatory DNA Sequences Maripat Corr and Chih Min Tang Immunostimulatory DNA Pre-Priming for the Induction of Th1 and Prevention of Th2 Biased Immune Responses Hiroko Kobayashi, Elena Martin-Orozco, Kenji Takabayashi, and Anthony A. Horner ProteinImmunostimulatory DNAConjugate: A Novel Immunogen Kenji Takabayashi, Helen Tighe, Lucinda Beck, and Hans L. Spiegelberg Immunostimulatory DNA Sequence-Based Mucosal Vaccines Anthony A. Horner Enhancement of the Immunoadjuvant Activity ofImmunostimulatory DNA Sequence by Liposomal Delivery Eli Kedar, Igal Louria-Hayon, Aviva Joseph, Zichria Zakay-Rones, Tomoko Hayashi, Kenji Takabayashi, and Yechezkel Barenholz. Immunostimulatory Sequences in Plasmid Vectors Christina C. N. Wu, Chih Min Tang, Brian Crain, and Maripat Corr Part V. Applications-Infectious Disease Comparison of CpG DNA with Other Adjuvants for Vaccination Against Hepatitis B Michael J. McCluskie, Risini D. Weeratna, and Heather L. Davis Immunostimulatory DNA-Based Immunization: Hope for an HIV Vaccine? Sandip K. Datta, Anthony A. Horner, Kenji Takabayashi, and Eyal Raz Immunoprotective Activity of CpG Oligonucleotides Dennis M. Klinman, Ken J. Ishii, and Ihsan Gursel Protective Immunity of Immunostimulatory Sequences Against Mycobacterial Infection Tomoko Hayashi, Christine H. Tran, Lucinda Beck, Savita Rao, and Antonino Cantanzaro Part VI. Applications-Allergy DNABased Immunotherapeutics for Allergic Disease Anthony A. Horner and Eyal Raz Immunostimulatory DNA for Allergic Asthma Reid K. Ikeda, Kenji Takabayashi, and David Broide CpG Oligodeoxynucleotides in Asthma Kunihiko Kitagaki and Joel N. Kline Modulation of Allergic Conjunctivitis by Immunostimulatory DNA Sequence Oligonucleotides Andrea KeaneMyers and ChiChao Chan Part VII. Applications-Cancer CpG Oligodeoxynucleotides and Monoclonal Antibody Therapy of Lymphoma Thomas L. Warren and George J. Weiner Part VIII. Inflammation and Autoimmunity The Antigenicity of Bacterial DNA David S. Pisetsky Inflammatogenic Properties of Immunostimulatory DNA Sequences Andrej Tarkowski, L. Vincent Collins, Guo-Min Deng, and Leno Mölne The Role of Immunostimulatory DNA Sequences in Arthritis Sarah T.A. Roord, Arash Ronaghy, Berent J.

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